Ultrasonic synthesis of Zn(II) methionine and ZnO nanostructures as a new precursor for ZnO nanoparticles and in-vitro study

Document Type : Research Article


1 Department of Chemical Technologies, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran

2 Department of Agriculture, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran


Zinc(II) ions play a special role in biological systems. Methionine is a sulphur containing amino acid with IUPAC name 2-amino-4-(methylthio)butanoic acid. In this study, ultrasonic synthesis and characterization of nanostructured Zn(II) methionine (Zn-Meth) in two different solvents were investigated. The reaction of ZnCl2 and methionine ligand under ultrasonic irradiation in both methanol and DMSO leads to the formation of nano-sized Zn(II) methionine complexes. Characterization of the Zn(II) complex was performed using elemental analysis, FT-IR spectroscopy, X-ray powder diffraction (XRD), thermal gravimetry (TGA), field emission scanning electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopy (EDS). The nano Zn-Meth complex, [Zn(CH3SCH2CH2CHNH2COOH)2]n, was then used as a precursor to obtaining the nano ZnO particle. An in-vitro study of the everted gut sac was also done on this complex to measure the uptake amount of zinc. The results showed that the nano-sized Zn-Meth has a higher absorption compared to its commercial and inorganic forms.

Graphical Abstract

Ultrasonic synthesis of Zn(II) methionine and ZnO nanostructures as a new precursor for ZnO nanoparticles and in-vitro study


  • A new synthetic method for the nanostructures of Zn-methionine complex by ultrasonic irradiations in two different solvents has reported.
  • ZnO nanoparticles were synthesized in 700 ºC for 2 hours under ambient atmospheric condition by using the nano Zn-methionine complex as precursor.
  • Zn-methionine nano-complex were used as zinc source to measure the absorption of it in everted sac method.


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