The growing complexity of modern medicine necessitates advanced drug delivery systems (DDS) that surpass the limitations of conventional methods in safety, efficacy, and personalization. This review explores innovative materials—such as lipid nanoparticles, hydrogels, dendrimers, metal–organic frameworks, exosomes, silica nanoparticles, and stimuli-responsive polymers—and their potential to achieve targeted, controlled, and responsive drug release. Their biocompatibility, drug-loading efficiency, targeting specificity, and translational readiness have been assessed based on recent literature and clinical data. Furthermore, a five-phase roadmap (2025–2045) has been proposed, charting the anticipated evolution of drug delivery systems (DDS)—from material optimization and hybrid nanosystems to AI-driven design, clinical translation, and sustainable bio-integrated platforms. Emerging technologies—like CRISPR-gated hydrogels, magnetothermal brain tumor delivery, and exosome-based RNA therapies—are highlighted as key drivers of future innovation. Despite significant promise, challenges remain in regulatory alignment, scalability, and long-term safety. This review underscores the need for interdisciplinary collaboration and strategic investment to translate laboratory breakthroughs into real-world solutions—paving the way for precision medicine, equitable access, and sustainable therapeutic delivery.
Gholampoor, M. and Mortezavy, A. (2025). Review of Advanced Materials Technology for Targeted and Sustained Drug Delivery with the Aim of Developing a Roadmap. Journal of Particle Science and Technology, (), -. doi: 10.22104/jpst.2025.7626.1279
MLA
Gholampoor, M. , and Mortezavy, A. . "Review of Advanced Materials Technology for Targeted and Sustained Drug Delivery with the Aim of Developing a Roadmap", Journal of Particle Science and Technology, , , 2025, -. doi: 10.22104/jpst.2025.7626.1279
HARVARD
Gholampoor, M., Mortezavy, A. (2025). 'Review of Advanced Materials Technology for Targeted and Sustained Drug Delivery with the Aim of Developing a Roadmap', Journal of Particle Science and Technology, (), pp. -. doi: 10.22104/jpst.2025.7626.1279
CHICAGO
M. Gholampoor and A. Mortezavy, "Review of Advanced Materials Technology for Targeted and Sustained Drug Delivery with the Aim of Developing a Roadmap," Journal of Particle Science and Technology, (2025): -, doi: 10.22104/jpst.2025.7626.1279
VANCOUVER
Gholampoor, M., Mortezavy, A. Review of Advanced Materials Technology for Targeted and Sustained Drug Delivery with the Aim of Developing a Roadmap. Journal of Particle Science and Technology, 2025; (): -. doi: 10.22104/jpst.2025.7626.1279
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