Sonochemical Synthesis of γ-Fe2O3 Nanoparticles for Hyperthermia

Articles in Press

Document Type : Research Article

Authors

1 Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran

2 Department of Chemical Engineering, Shahreza Branch, Islamic Azad University, Shahreza, Iran

Abstract

This study addresses the limitations of conventional cancer treatments, such as chemotherapy and radiotherapy, by focusing on the synthesis and characterization of superparamagnetic γ-Fe2O3 nanoparticles (GMNP) using the sonochemical method for hyperthermia-based cancer therapy. While previous studies have explored the use of magnetic nanoparticles in cancer treatment, their efficiency and quality have remained suboptimal. In this study, we propose a sonochemical approach to enhance the quality and performance of GMNPs. The sonochemical method improved nanoparticle quality and efficiency. The GMNPs demonstrated a significant hyperthermic effect, with a temperature increase exceeding 43°C under an alternative magnetic field (that will be referred to as ACMF in abbreviations) (400 kHz), Which can help induce apoptosis and necrosis in cancer cells. The nanoparticles were spherical in shape, with sizes ranging from 20 to 51 nm. Cytotoxicity assays (MTT assay) showed that the nanoparticles maintained high biocompatibility, with cell viability above 75% at all concentrations. These findings suggest that GMNPs synthesized via the sonochemical method offer improved efficacy compared to traditional methods, making them a promising candidate for hyperthermia-based cancer therapy.

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Journal of Particle Science and Technology

Articles in Press, Accepted Manuscript
Available Online from 09 March 2025

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History

  • Receive Date: 20 December 2024
  • Revise Date: 26 January 2025
  • Accept Date: 28 February 2025

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