Iranian Research Organization for Science and Technology Journal of Particle Science and Technology 2423-4087 1 3 2015 09 01 Synthesis and structural properties of Polyvinylpyrrolidone based nanocomposite hydrogels for isoniazid drug delivery 183 193 263 10.22104/jpst.2015.263 EN Hassan FathinrjadJirandehi Young Researchers and Elite Club, Farahan Branch, Islamic Azad University, Farahan, Iran Maryam Adimi Young Researchers and Elite Club, Farahan Branch, Islamic Azad University, Farahan, Iran Mokhtar Heydari Naqdali Department of Chemical Engineering, Farahan Branch, Islamic Azad University, Farahan , Iran Journal Article 2016 02 09 In this study, several examples of hydrogels and nanocomposite hydrogels based on PVP with different content of montmorillonite nanoclay were prepared. Then, the swelling of hydrogels and kinetics of drug delivery of hydrogel in an environment similar to the body (pH 7.4) were examined. The effect of nanoparticle different percentages on the hydrogel was clearly observed. Then kinetics of drug (Isoniazid) delivery for various samples of hydrogel with nanoparticles and without nanoparticles were obtained via Peppas and Higuchi models. The comparison of Peppas model results with experimental data showed that nanocomposite with 4% nanoclay exhibited better compliance. The morphology and microstructure of the prepared nanocomposites were studied by FT-IR, XRD and SEM. https://jpst.irost.ir/article_263_8c19f571e251e61cb8dd3612f26d5ecf.pdf