Iranian Research Organization for Science and Technology Journal of Particle Science and Technology 2423-4087 11 1 2025 06 30 Review of advanced materials technology for targeted and sustained drug delivery with the aim of developing a roadmap 11 25 1560 10.22104/jpst.2025.7626.1279 EN Mahdi Gholampour Department of Physics, Faculty of Basic Sciences, Imam Ali Officers' University, Tehran, Iran Journal Article 2025 05 22 The growing complexity of modern medicine necessitates advanced drug delivery systems (DDS) that surpass the limitations of conventional methods in safety, efficacy, and personalization. This review examines innovative materials, including lipid nanoparticles, hydrogels, dendrimers, metal–organic frameworks, exosomes, silica nanoparticles, and stimuli-responsive polymers, and their potential to achieve targeted, controlled, and responsive drug release. Their biocompatibility, drug-loading efficiency, targeting specificity, and translational readiness have been assessed based on recent literature and clinical data. Furthermore, a five-phase roadmap (2025–2045) has been proposed, outlining the anticipated evolution of drug delivery systems from material optimization and hybrid nanosystems to AI-driven design, clinical translation, and sustainable bio-integrated platforms. Emerging technologies, like CRISPR-gated hydrogels, magnetothermal brain tumor delivery, and exosome-based RNA therapies, are highlighted as key drivers of future innovation. Despite significant promise, challenges remain in regulatory alignment, scalability, and long-term safety. This review underscores the need for interdisciplinary collaboration and strategic investment to translate laboratory breakthroughs into real-world solutions, thereby paving the way for precision medicine, equitable access, and sustainable therapeutic delivery. https://jpst.irost.ir/article_1560_2c78f036f9144d0f47ff0d7ece5c34ae.pdf