Ultrasonic synthesis of Zn(II)methionine nanostructures: as precursor for ZnO nanoparticles and in vitro study

Document Type: Research Paper


1 Iranian Research for Science and Technology

2 Department of Chemical Technologies, Iranian Research Organization for Science and Technology, Tehran, Iran

3 Department of Agriculture, Iranian Research Organization for Science and Technology, Tehran, Iran



Zinc(II) ions has special role in biological systems Methionine with IUPAK name 2-amino-4-(methylthio)butanoic acid is one of Sulphur containing amino acids. In this study, ultrasonic synthesis and characterization of nanostructured Zn(II)methionine (Zn-Meth) in two different solvents, were investigated. The reaction of ZnCl2 and methionine ligand under ultrasonic irradiation in methanol and DMSO separately, leads to the formation of nano-sized Zn(II)methionine complexes. Characterization of the Zn(II) complex, has been performed using elemental analysis, FTIR spectroscopy, X-ray powder diffraction XRD, Thermal gravimetry, and field emission scanning electron microscopy (FE-SEM) and EDS. Nano Zn-Meth nano complex, [Zn(CH3CH2CH2CHNHHCOOH)2]n , has been used as a precursor to obtaining Nano ZnO particle. On this complex also in vitro study of the everted gut sack has been done, to measure the uptake amount of zinc and it shows nano-sized Zn-Meth has higher absorption compared to commercial and inorganic form.


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