Combustion synthesis of sponge-like CeO2 powder for selective determination of uric acid in biological fluids

Document Type : Research Article

Authors

1 Inorganic Research Laboratory, Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran

2 Department of Materials Engineering, Faculty of Engineering, University of Sistan and Baluchestan, Zahedan, Iran

3 Analytical Research Laboratory, Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran

Abstract

Sponge-like porous cerium oxide particles were prepared through the self-propagating high-temperature synthesis process. Then, the synthesized powder was used to modify the carbon paste electrode (CPE/porous CeO2) for voltammetric determination of uric acid (UA) in biological fluids. Under optimal conditions, the linear concentration-response relationship was in the range of 0.25-10 and 10-300 µM, and a detection limit of 60 nM (S/N=3) was obtained. In addition, the proposed sensor showed excellent selectivity towards UA over common co-existing species such as ascorbic acid, ibuprofen, dopamine, and acetaminophen. Good repeatability of sensor responses (Relative standard deviation (RSD) < 3.2%), superior reproducibility (RSD < 2.8%), and excellent storage stability (error < 5% after 1 month storage at room temperature) along with appropriate recovery values (in the range of 99.2 -102.7%) demonstrate the applicability of CPE/porous CeO2 for the determination of UA levels in biological fluids. 

Graphical Abstract

Combustion synthesis of sponge-like CeO2 powder for selective determination of uric acid in biological fluids

Highlights

  • Synthesis of porous Mg-doped CeO2 powder by the combustion synthesis route.
  • Application of synthesized porous CeO2 powder for selective determination of uric acid.
  • Obtaining excellent results for ultra-trace voltammetric determination of UA.

Keywords

References

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Journal of Particle Science and Technology
Volume 7, Issue 2
October 2021
Pages 73-82

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History

  • Receive Date: 09 April 2022
  • Revise Date: 28 May 2022
  • Accept Date: 02 June 2022

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